Nicholas Brendon, best known for portraying the loyal, wisecracking Xander Harris in “Buffy the Vampire Slayer,” died Friday from natural causes after dealing with a congenital heart defect and other health issues in recent years.

Hannigan's post featured a still of Brendon and herself embracing on an episode of Buffy. Hannigan and Brendon were both series regulars on Buffy during its seven-season run from

Nicholas Brendon was best known for his role as Xander Harris on all seven seasons of "Buffy the Vampire Slayer."

As fans and loved ones mourn the death of Nicholas Brendon, his 'Buffy the Vampire Slayer' co-stars are paying tribute.

Nicholas Brendon, who played Xander on all seven seasons of TV's Buffy the Vampire Slayer, has died. He was 54. His family confirmed his death in a statement on social media: "We are heartbroken to share the passing of our brother and son,

Actor Nicholas Brendon, who co-starred on TV's Buffy the Vampire Slayer as Xander Harris, has died, according to a statement from his family posted on social media.

Nicholas Brendon, who played Xander Harris in Buffy the Vampire Slayer, died in his sleep of natural causes on March 20, his family shared. He was 54.

Actor Nicholas Brendon, best known for his role as Xander Harris on the TV series Buffy the Vampire Slayer from 1997 to 2003, has died. He was 54. Brendon died on Friday, March 20, according to a statement shared with The Hollywood Reporterfrom his family.