The activation of the α-carbons of carboxylic esters and related carbonyl compounds to generate enolate equivalents as nucleophiles is one of the most powerful strategies in organic synthesis. We ...

You may have seen a warning, that when you detect a vinegar smell from your bottle of aspirin it's time to toss it. But is this really a concern? Here are a few facts you may not know. But there are ...

Although it's been around for 30 years, the Barton-McCombie deoxygenation--in which an alcohol is converted to a xanthate ester, enabling replacement of the hydroxyl with a hydrogen atom via a radical ...

Amide bond-forming reactions are of tremendous significance in synthetic chemistry. Methodological research has, in the past, focused on efficiency and selectivity, and these have reached impressive ...